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	Provedor de dados BJMBR (2) Anais da ABC (AABC) (1) Autor Andersen,M.L. (1) Castilho,Roger F. (1) Degasperi,Giovanna R. (1) Felipe,C.R. (1) Garcia,R. (1) Machado,P.G. (1) Martins,R.C.S. (1) Medina-Pestana,J.O. (1) Park,S.I. (1) Ruiz,F.S. (1) Schmouder,R. (1) Skerjanec,A. (1) Tedesco-Silva Jr.,H. (1) Tufik,S. (1) Vercesi,Anibal E. (1) Zager,A. (1) Mais... Palavra-chave Lymphopenia (3) Cell death (1) Diabetes (1) FTY720 (1) Free radicals (1) Immune response (1) Immunosuppression (1) Mitochondrial permeability transition (1) Non-obese diabetic mouse (1) Pharmacodynamics (1) Pharmacokinetics (1) Renal transplants (1) Sleep deprivation (1) Spleen lymphocyte (1) Stress (1) Swiss mice (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Info:eu-repo/semantics/other (1) Ano 2008 (1) 2007 (1) 2005 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última High susceptibility of activated lymphocytes to oxidative stress-induced cell death Anais da ABC (AABC) Degasperi,Giovanna R.; Castilho,Roger F.; Vercesi,Anibal E.. The present study provides evidence that activated spleen lymphocytes from Walker 256 tumor bearing rats are more susceptible than controls to tert-butyl hydroperoxide (t-BOOH)-induced necrotic cell death in vitro. The iron chelator and antioxidant deferoxamine, the intracellular Ca2+ chelator BAPTA, the L-type Ca2+ channel antagonist nifedipine or the mitochondrial permeability transition inhibitor cyclosporin A, but not the calcineurin inhibitor FK-506, render control and activated lymphocytes equally resistant to the toxic effects of t-BOOH. Incubation of activated lymphocytes in the presence of t-BOOH resulted in a cyclosporin A-sensitive decrease in mitochondrial membrane potential. These results indicate that the higher cytosolic Ca2+ level in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cell death; Free radicals; Immune response; Lymphopenia; Mitochondrial permeability transition; Spleen lymphocyte. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000100009 Pharmacokinetic/pharmacodynamic relationships of FTY720 in kidney transplant recipients BJMBR Park,S.I.; Felipe,C.R.; Machado,P.G.; Garcia,R.; Skerjanec,A.; Schmouder,R.; Tedesco-Silva Jr.,H.; Medina-Pestana,J.O.. FTY720 is a new and effective immunosuppressive agent, which produces peripheral blood lymphopenia through a lymphocyte homing effect. We investigated the relationship between the dose of FTY720 or blood concentration (pharmacokinetics, PK) and peripheral lymphopenia (pharmacodynamics, PD) in 23 kidney transplant recipients randomized to receive FTY720 (0.25-2.5 mg/day) or mofetil mycophenolate (2 mg/day) in combination with cyclosporine and steroids. FTY720 dose, blood concentrations and lymphocyte counts were determined weekly before and 4 to 12 weeks after transplantation. The effect of PD was calculated as the absolute lymphocyte count or its reductions. PK/PD modeling was used to find the best-fit model. Mean FTY720 concentrations were 0.36 ± 0.05... Tipo: Info:eu-repo/semantics/article Palavras-chave: FTY720; Lymphopenia; Pharmacokinetics; Pharmacodynamics; Immunosuppression; Renal transplants. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000500005 Sleep deprivation reduces the lymphocyte count in a non-obese mouse model of type 1 diabetes mellitus BJMBR Ruiz,F.S.; Andersen,M.L.; Zager,A.; Martins,R.C.S.; Tufik,S.. The objective of the present study was to determine whether sleep deprivation (SD) would promote changes in lymphocyte numbers in a type 1 diabetes model (non-obese diabetic, NOD, mouse strain) and to determine whether SD would affect female and male NOD compared to Swiss mice. The number of lymphocytes in peripheral blood after 24 and 96 h of SD (by multiple platform method) or equivalent period of time in home-cage controls was examined prior to the onset of diabetes. SD for 96 h significantly reduced lymphocytes in male Swiss mice compared to control (8.6 ± 2.1 vs 4.1 ± 0.7 10³/µL; P < 0.02). In male NOD animals, 24- and 96-h SD caused a significant decrease of lymphocytes compared to control (4.4 ± 0.3 vs 1.6 ± 0.5; P < 0.001 and 4.4 ± 0.3 vs 0.9... Tipo: Info:eu-repo/semantics/other Palavras-chave: Sleep deprivation; Stress; Lymphopenia; Diabetes; Non-obese diabetic mouse; Swiss mice. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000500005 Registros recuperados: 3 Primeira ... 1 ... Última

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